New breakthroughs in the development of medical micro nano robots

Science and Technology Daily (reporter Li Liyun) A reporter recently learned from Harbin Institute of Technology that a water simulating bear insect medical micro nano robot jointly developed by researchers from Harbin Institute of Technology and Harbin Medical University has preliminarily realized controllable movement in the high-speed flow environment of venous blood, and can stay in venous blood flow for more than 36 hours.The relevant research results were recently published online in the latest issue of "Progress in Science"

Science and Technology Daily (reporter Li Liyun) A reporter recently learned from Harbin Institute of Technology that a water simulating bear insect medical micro nano robot jointly developed by researchers from Harbin Institute of Technology and Harbin Medical University has preliminarily realized controllable movement in the high-speed flow environment of venous blood, and can stay in venous blood flow for more than 36 hours.

The relevant research results were recently published online in the latest issue of "Progress in Science". At the same time, the internationally renowned Nature magazine reported and commented on the research highlight of "Providing grip for swimming micro/nano robots with a water like bear claw structure". Experts believe that if this achievement can complete clinical transformation in the future, it is expected to significantly improve the efficiency of drug targeted delivery, and bring bright prospects for the suppression of pancreatic cancer, pancreatitis and other tumor diseases.

Experts introduce that conventional drug delivery, such as injection, medication, and intravenous infusion, is carried out by the diffusion of drug molecules or carriers in fluids such as blood. These drug molecules or carriers diffuse with biological fluids such as blood flow, resulting in low delivery efficiency and severe toxic side effects. Scholars have conducted statistics on drug delivery methods in the past 30 years and found that less than 1% of drugs arrive at their destination 12 hours after delivery. This means that the vast majority of drugs have been lost on the "mail route". Currently, the rapidly developing micro/nano robots have gradually emerged in fields such as biomedical, anti-tumor targeted drug delivery, and laboratory testing due to their advantages and characteristics of small size, light weight, high thrust to weight ratio, and the ability to cross multiple biological barriers.

But how to ensure that micro and nano robots stand firm and drive freely under the high-speed scouring of blood flow? How to build a solid drug transport "channel" to achieve targeted release within the circulatory system? These issues remain major challenges for the medical community.

With the support of various projects such as the National Key R&D Program and the National Natural Science Foundation of China, the team of the National Key Laboratory of Robotics Technology and Systems at Harbin Institute of Technology collaborated with experts from the General Surgery Department of the First Affiliated Hospital of Harbin Medical University to jointly carry out the research on the "Water Bear Insect like Medical Micro Nano Robot that Can Target and Stop in the Blood Vessel", and successfully designed the Water Bear Insect like Medical Micro Nano Robot.

This type of robot has "claws" like water bears, which can significantly improve the driving efficiency of micro nano robots and make them "run faster". Using medical optical coherence tomography technology, researchers found that a robot with a diameter of 20 microns can move efficiently in a vein blood flow environment of 20000 microns/second; To make the robot "stop", the research team also utilized multi magnetic field composite regulation technology to allow micro/nano robots to stay on the surface of biological tissues for a long time and release targeted drugs.

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