Research Reveals the Structure and Self Inhibition Mechanism of Glycosylphosphatidylinositol Transamidase Complex Binding to Ligands
[Source: Shanghai Municipal Government Today Shanghai Industry Information]Recently, NatureCommunications published online the research results of Li exemplary research group of the Center for Excellence and Innovation in Molecular Cell Science of the Chinese Academy of Sciences and Qu Qianhui research group of Fudan UniversityGlycosylphosphatidylinositol TransamidaseIlluminateGPI-APBiogenesis reveals the structural basis of glycosylphosphatidylinositol (GPI) transamidase (GPI-T) complexes for recognizing a wide range of substrates and the self inhibitory mechanism for preventing accidental shear.GPI modification is a common post translational modification in eukaryotes...
The persistence of ALG-125755 in mouse liver pharmacodynamics is associated with total siRNA and RISC binding siRNA
At the 2023 European Liver Conference (EASL 2023), researchers from the American clinical stage biopharmaceutical company AligosTherapeutics introduced another latest progress in the development of small interfering RNA (siRNA) ALG-125755 drugs,The pharmacodynamic persistence of ALG-125755 (a GalNAc binding siRNA) in mouse liver is related to the total siRNA and RNA inducible complex (RISC) binding siRNA.This study is sourced from Aligos Corporation, EASL2023The researchers introduced that the continuous disappearance of HBsAg (HBsAg) is required to achieve functional cure of chronic hepatitis B...
Reminder: Binding bank cards on WeChat may also pose serious security risks! Look early, avoid early!
With the continuous development of the Internet, WeChat has also entered our lives and become an irreplaceable communication tool. It is precisely because WeChat is very convenient that both men, women, and children can easily control it...