Research Reveals the Structure and Self Inhibition Mechanism of Glycosylphosphatidylinositol Transamidase Complex Binding to Ligands
[Source: Shanghai Municipal Government Today Shanghai Industry Information]Recently, NatureCommunications published online the research results of Li exemplary research group of the Center for Excellence and Innovation in Molecular Cell Science of the Chinese Academy of Sciences and Qu Qianhui research group of Fudan UniversityGlycosylphosphatidylinositol TransamidaseIlluminateGPI-APBiogenesis reveals the structural basis of glycosylphosphatidylinositol (GPI) transamidase (GPI-T) complexes for recognizing a wide range of substrates and the self inhibitory mechanism for preventing accidental shear.GPI modification is a common post translational modification in eukaryotes...