The persistence of ALG-125755 in mouse liver pharmacodynamics is associated with total siRNA and RISC binding siRNA
At the 2023 European Liver Conference (EASL 2023), researchers from the American clinical stage biopharmaceutical company AligosTherapeutics introduced another latest progress in the development of small interfering RNA (siRNA) ALG-125755 drugs,The pharmacodynamic persistence of ALG-125755 (a GalNAc binding siRNA) in mouse liver is related to the total siRNA and RNA inducible complex (RISC) binding siRNA.This study is sourced from Aligos Corporation, EASL2023The researchers introduced that the continuous disappearance of HBsAg (HBsAg) is required to achieve functional cure of chronic hepatitis B...